The basic tenet of the ROX hypothesis is that post-hemoglobin, O2 transport to and focus at its target site, depends on an elegant mechanism involving the shuttling of O2 in and out of reservoirs in blood and other fluids.
Oxygen drives the body’s life process by combining with food to generate energy for muscular activity, nervous system conduction, immune attack against cancer and viruses and bacteria, detoxification of ingested pollutants and drugs and energy for signaling immune- and nervous-system functions.
An essential and convenient way to study the availability of energy for the body is to track the delivery of oxygen to tissues. Fuels such as glucose and fats must be oxidized in order to release their energy. Each molecule of glucose requires six molecules of oxygen in order to release its energy. A single molecule of fat can require dozens of molecules of oxygen to unleash its energy stores. In terms of numbers of molecules required for energy, the supply of oxygen is far more critical than the supply of sugars and fats.
Oxygen is the rate-limiting substance for energy generation. Therefore, the simplest way to observe the body’s availability of energy, is to measure the blood’s ability to deliver the oxygen and to focus it at the point of need. This is done by using the Immunogram as a tool.
Our bodies are mainly made of water. But, while sugar and other energy molecules are soluble in water, oxygen is not. For example, the normal blood sugar level is about 100 mg/dl or about 1,000 parts per million (ppm), but oxygen can only dissolve in tissues and plasma to about the 6 ppm level. This is less than 1% of the oxygen needed for glucose oxidation, whereas greater than 1,000 parts per million are needed.
So how can sufficient amounts of oxygen be delivered to, for example, the mitochondrion, an organelle inside the cell, where it is needed for processing sugar into energy?
When a sample of blood is subjected to increasing amounts of shear- and chemical- stress in an IA cell, an Immunogram is generated, measuring the amounts of oxygen and nitric oxide (NO) that are released as the ROX breaks.
Oxygen is paramagnetic and is stored in very concentrated form inside tiny ROX capsules which are also paramagnetic. A magnetic signal such as superoxide attracts paramagnetic compounds such as oxygen and NO, causing the ROX to swarm to the point of the signal. The swarm then releases all the oxygen or NO in concentrated form at one location.